PDF Prognostic value of PTEN loss in men with

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The prognostic value of PTEN,p53,and beta-catenin in

Mutations of the PTEN,p53,and beta-catenin genes are the most frequent molecular defects in endometrial carcinomas.The aim of this study was to investigate their prognostic significance in this form of cancer.Imprint smears were obtained from 80 fresh endometrial tumor specimens and studied immunocytochemically for the expression of PTEN,p53,and beta-catenin proteins.The prognostic value of PTEN,p53,and beta-catenin in Mutations of the PTEN,p53,and beta-catenin genes are the most frequent molecular defects in endometrial carcinomas.The aim of this study was to investigate their prognostic significance in this form of cancer.Imprint smears were obtained from 80 fresh endometrial tumor specimens and studied immunocytochemically for the expression of PTEN,p53,and beta-catenin proteins.The combination of PTEN deletion and 16p13.3 gain in Aug 23,2018 PDF Prognostic value of PTEN loss in men with#0183;Cuzick J,Yang ZH,Fisher G,Tikishvili E,Stone S,Lanchbury JS,et al.Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.British journal of

The combination of PTEN deletion and 16p13.3 gain in

Aug 23,2018 PDF Prognostic value of PTEN loss in men with#0183;Cuzick J,Yang ZH,Fisher G,Tikishvili E,Stone S,Lanchbury JS,et al.Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.British journal ofProstate Cancer Prognosis Defined by the Combined PDF Prognostic value of PTEN loss in men with#0183;To assess the prognostic value of ERG and PTEN protein expression as two of the most common genetic aberration in men with prostate cancer managed non-surgically by androgen deprivation therapy (ADT).463 tumor samples were assessed by double immunohistochemistry stains for ERG and PTEN and data correlated with clinical pathological features including,Gleason score,patientsPrognostic value of PTEN loss in men with conservatively Jun 25,2013 PDF Prognostic value of PTEN loss in men with#0183;The natural history of prostate cancer is highly variable and difficult to predict.We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.

Prognostic value of PTEN loss in men with conservatively

Enter the password to open this PDF file Cancel OK.File name:-Prognostic value of PTEN loss in men with conservatively Abstract.Background:The natural history of prostate cancer is highly variable and difficult to predict.We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.Methods:The PTEN status was assayed by immunohistochemistry (PTEN IHC) andPrevious123456NextClinical implications of PTEN loss in prostate cancer Feb 20,2018 PDF Prognostic value of PTEN loss in men with#0183;Download PDF.Published 20 February 2018; Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.Br.J.Cancer 108,25822589 (2013).

Prevalence and Prognostic Significance of PTEN Loss in

May 01,2017 PDF Prognostic value of PTEN loss in men with#0183;Finally,the association between PTEN loss and BCR did not differ significantly by race when the original set of 338 matched EA and AA men was included in a multivariable model with the same variables as in Table 2 (interaction term for AA race and PTEN loss,HRPrevalence and Prognostic Significance of PTEN Loss in May 01,2017 PDF Prognostic value of PTEN loss in men with#0183;Finally,the association between PTEN loss and BCR did not differ significantly by race when the original set of 338 matched EA and AA men was included in a multivariable model with the same variables as in Table 2 (interaction term for AA race and PTEN loss,HRPTEN loss in biopsy tissue predicts poor clinicalrized in Table 1.Of the 77 men,nine (12%) had PTEN loss.PTEN status and clinical outcomes During a median follow-up period of 8.8 years,39 men (51%) developed BCR,20 men (26%) went on to receive ADT,four (5%) had CRPC,and two (3%) had progressed to metastatic disease and eventually died from PC.In our primary analysis,

PTEN Loss is Associated with Upgrading of Prostate Cancer

Because we and others have showed that PTEN protein loss and underlying gene deletion is most commonly focal [24,35],it is likely that we missed a number of cases with focal PTEN protein loss by evaluating PTEN status in only one core.Future studies will assess whether evaluation of PTEN status on all cancer-containing needle cores may Molecular prognostic tests for prostate cancer - UpToDateJan 28,2020 PDF Prognostic value of PTEN loss in men with#0183;Cuzick J,Yang ZH,Fisher G,et al.Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.Br J Cancer 2013; 108:2582.Lotan TL,Gurel B,Sutcliffe S,et al.PTEN protein loss by immunostaining analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients.Loss of PTEN expression is an independent predictor of Aug 15,2013 PDF Prognostic value of PTEN loss in men with#0183;Among various prognostic factors,loss of PTEN expression,age 70,G 1,FIGO stage III/IV,muscular invasion PDF Prognostic value of PTEN loss in men withgt;1/2,and presence of LVI were

Loss of PTEN expression is an independent predictor of

Aug 15,2013 PDF Prognostic value of PTEN loss in men with#0183;Among various prognostic factors,loss of PTEN expression,age 70,G 1,FIGO stage III/IV,muscular invasion PDF Prognostic value of PTEN loss in men withgt;1/2,and presence of LVI wereLoss of PTEN expression in ERG-negative prostate cancer Aug 26,2016 PDF Prognostic value of PTEN loss in men with#0183;Cuzick J,Yang ZH,Fisher G et al.Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.Br J Cancer 2013; 108 :25822589.CASLoss of PTEN expression in ERG-negative prostate cancer Aug 26,2016 PDF Prognostic value of PTEN loss in men with#0183;Cuzick J,Yang ZH,Fisher G et al.Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.Br J Cancer 2013; 108 :25822589.CAS

Loss of PTEN Is Associated with Aggressive Behavior in ERG

In the regression-tree analysis,PTEN showed prognostic value in subgroups of tumors with pT2 stage,GS 7 and ERG positivity as well as in tumors with pT2,GS PDF Prognostic value of PTEN loss in men withlt;7 and 10 ng/mL PDF Prognostic value of PTEN loss in men withlt;PSA30 ng/mL (Supplementary Fig.S3).PTEN loss was also significantly associated with hemizygous deletion of TP53 (P = 0.0281,Supplementary Table S9).Loss of PTEN Expression as a Prognostic Marker for Tongue In summary,we have demonstrated that loss of PTEN is not a rare event in SCC of the tongue and bears an independent prognostic value,therefore suggesting that PTEN plays an important role in tongue tumorigenesis and progression of disease.Accepted for publication July 25,2001.In depth evaluation of the prognostic and predictive studies have found prognostic value for nuclear PTEN loss [1316].Another study revealed that PTEN pro-tein localizes to the cytoplasm of both normal and tumor cells and no correlation of immunostaining and tumor characteristics could be confirmed [17].Thus,the role of PTEN as a prognostic factor in CRC is still controversial [18].

Genomic rearrangements of PTEN in prostate cancer

In this four-color FISH assay design,loss of PTEN signal,but presence of BMPR1A and FAS signals,indicates with a higher degree of accuracy that a PTEN deletion is present rather than a false-positive resulting from truncation effects.Loss of PTEN signal along with loss of anking probe signals could suggest PTEN PTEN PTEN ().).Frequency and Prognostic Value of PTEN Loss in Patients Patients with PTEN loss had significantly advanced pathological tumor stage and grade (p PDF Prognostic value of PTEN loss in men withlt;0.001),higher rates of lymph node metastasis (p PDF Prognostic value of PTEN loss in men withlt;0.01),and lymphovascular invasion (p PDF Prognostic value of PTEN loss in men withlt;0.001) compared to Frequency and Prognostic Value of PTEN Loss in Patients Patients with PTEN loss had significantly advanced pathological tumor stage and grade (p PDF Prognostic value of PTEN loss in men withlt;0.001),higher rates of lymph node metastasis (p PDF Prognostic value of PTEN loss in men withlt;0.01),and lymphovascular invasion (p PDF Prognostic value of PTEN loss in men withlt;0.001) compared to

Cuzick,J; Yang,ZH; Fisher,G; Tikishvili,E; Stone,S

Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer J Cuzick*,1,Z H Yang 1,G Fisher ,E Tikishvili 2,S Stone ,J S Lanchbury ,N Camacho 3,S Merson ,D Brewer ,C S Cooper4,J Clark4,D M Berney5,H M PDF Prognostic value of PTEN loss in men with#248;ller6,P Scardino7 and Z Sangale2 on behalf of the Transatlantic Prostate Group 1Centre for Cancer Prevention,Wolfson Institute of Preventive Medicine Clinical implications of PTEN loss in prostate cancer Feb 20,2018 PDF Prognostic value of PTEN loss in men with#0183;Download PDF.Published 20 February 2018; Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.Br.J.Cancer 108,25822589 (2013).Clinical implications of PTEN loss in prostate cancer Feb 20,2018 PDF Prognostic value of PTEN loss in men with#0183;Download PDF.Published 20 February 2018; Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.Br.J.Cancer 108,25822589 (2013).

Cited by 69Publish Year 2013Author J Cuzick,Z H Yang,G Fisher,E Tikishvili,S Stone,J S Lanchbury,N Camacho,S Merson,D Brewer,CPrognostic value of PTEN loss in men with conservatively

May 21,2013 PDF Prognostic value of PTEN loss in men with#0183;The natural history of prostate cancer is highly variable and difficult to predict.We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 menCited by 69Publish Year 2013Author J Cuzick,Z H Yang,G Fisher,E Tikishvili,S Stone,J S Lanchbury,N Camacho,S Merson,D Brewer,CPrognostic value of PTEN loss in men with conservatively Abstract.Background:The natural history of prostate cancer is highly variable and difficult to predict.We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.Methods:The PTEN status was assayed by immunohistochemistry (PTEN IHC) andCited by 142Publish Year 2018Author Tamara Jamaspishvili,David M.Berman,Ashley E.Ross,Howard I.Scher,Angelo M.De Marzo,Jeremy ALoss of PTEN Expression Detected by Fluorescence Sep 01,2019 PDF Prognostic value of PTEN loss in men with#0183;J.Cuzick,Z.H.Yang,G.Fisher,et al.Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer Br J Cancer,

A gene signature associated with PTEN activation defines

Jan 24,2018 PDF Prognostic value of PTEN loss in men with#0183;These PTENH cases were marked by the differential expression of a panel of 35 genes that discriminate them from the other two subtypes (PTENM and PTENL).This geneset profile shows significant prognostic effect across three independent datasets that we interrogated (HR of 6.95,6.4,and 1.77,all p PDF Prognostic value of PTEN loss in men withlt; 0.01) (Figure 5 and supplementary 12345NextPrognostic value of PTEN loss in men with conservatively Abstract.Background The natural history of prostate cancer is highly variable and difficult to predict.We report on the prognostic value of phosphatase and tensin homologue (PTEN) loss in a cohort of 675 men with conservatively managed prostate cancer diagnosed by transurethral resection of the prostate.(PDF) Role of ERG,PTEN and KI67 Proteins Expression in 2) Lotan TL,Gurel B,Sutcli ffe S,et al.PTEN protein loss by immunostaining analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients.Cli n

(PDF) Prognostic value of PTEN loss in men with

Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer.pdf Available via license CC BY-NC-SA 3.0 Content may be subject to copyright.(PDF) Loss of PTEN Expression Detected by Fluorescence The loss of PTEN expression associated with higher risk grade group Gleason is of the higher proportion with p=0.001; PR 3.339; 95% CI 1.2968.599,but there is no association between the (PDF) Cancer Prognosis Defined by the Combined AnalysisThe aim of this study was to evaluate the combined prognostic role of three frequent molecular alterations in prostate cancer,namely relative 8q gain,ERG overexpression,and loss of PTEN

(PDF) Cancer Prognosis Defined by the Combined Analysis

The aim of this study was to evaluate the combined prognostic role of three frequent molecular alterations in prostate cancer,namely relative 8q gain,ERG overexpression,and loss of PTEN

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